Loss of dysbindin-1 in mice impairs reward-based operant learning by increasing impulsive and compulsive behavior
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چکیده
منابع مشابه
Differential Roles of Nonsynaptic and Synaptic Plasticity in Operant Reward Learning-Induced Compulsive Behavior
BACKGROUND Rewarding stimuli in associative learning can transform the irregularly and infrequently generated motor patterns underlying motivated behaviors into output for accelerated and stereotyped repetitive action. This transition to compulsive behavioral expression is associated with modified synaptic and membrane properties of central neurons, but establishing the causal relationships bet...
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Feeding in Aplysia provides an amenable model system for analyzing the neuronal substrates of motivated behavior and its adaptability by associative reward learning and neuromodulation. Among such learning processes, appetitive operant conditioning that leads to a compulsive-like expression of feeding actions is known to be associated with changes in the membrane properties and electrical coupl...
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BACKGROUND Learning in exploratory and goal-directed behaviors can modify decision-making processes in the initiation of appropriate action and thereby transform the irregular and infrequent expression of such behaviors into inflexible, compulsive-like repetitive actions. However, the neuronal mechanisms underlying such learning-derived behavioral plasticity remain poorly understood. RESULTS ...
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ژورنال
عنوان ژورنال: Behavioural Brain Research
سال: 2013
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2012.12.021